When wild and eccentric Anna Cooper blows into the run-of-the-mill town of Billetsby, James Parrish, PhD strives to stay as far away from her as possible. As a series of serendipitous circumstances continue to pit the two in compromising positions, they resign themselves to the fact that they’ll have to learn to exist in the town together. Their uneasy partnership is solidified when a mysterious monster from the north ravages the town—a monster only James knows how to lure into a trap and Anna knows how to kill.
Anna and James begin to develop reluctant feelings for each other amid festive balls, chemistry lessons, and hunting trips. As more monsters continue to converge on Billetsby and the pair argues on the best way to deal with the threat, Anna and James must thrust their differences aside to save the town or work separately and risk their lives, as well as the lives of the townsfolk, in the name of pride.